Potential Contribution Research Articles

Evaluating Total Atherosclerosis Burden of Baroreceptor-Resident Arteries after Ischemic Cerebrovascular Disease for Identifying Patients with Heavy Coronary Atherosclerosis Burden.

The carotid sinuses and aortic arch are baroreceptor-resident arteries (BRAs) and atherosclerosis-susceptible sites of brain-supplying arteries, which would impair baroreflex-mediated blood pressure (BP) regulation and prompt coronary atherosclerosis. We sought to determine the relationship between total atherosclerosis burden (TAB) of BRAs and coronary atherosclerosis burden (AB) in patients with ischemic cerebrovascular disease (ICVD) and explore the potential contribution of BP profiles to this relationship. In this cross-sectional analysis of patients with ICVD who simultaneously undertook computed tomography angiography and 24-hour ambulatory BP monitoring, TAB of BRAs was scored based on the atherosclerotic vessel circumference ratio of the carotid sinuses and aortic arch, while the ABs of the intracranial, cervical, aortic, and coronary arteries were scored based on stenosis severity and plaque complexity as routine. Among the 230 patients analyzed, coronary AB was significantly correlated with TAB of BRAs, independently of, and more tightly than the ABs of the intracranial, cervical, and aortic arteries, and the stenosis- and complexity-based AB of BRA-located arteries (bilateral common and extracranial internal carotid arteries and aortic arch). Both coronary AB and TAB of BRAs were negatively associated with the night-to-day BP dipping ratios, which was quite different from the relationship between intracranial AB and 24-hour BP characteristics. These findings were also true for patients with ICVD without a history of coronary artery disease. Evaluating TAB of BRAs might provide a new link between atherosclerosis of brain- and heart-supplying arteries, connected partially by BP circadian rhythm. It might facilitate identifying patients with ICVD with heavy coronary AB and comprehensively managing vascular risk.

Comparative Analysis of Water Sustainability Indices: A Systematic Review

The achievement of water sustainability necessitates the development and application of comprehensive assessment tools to monitor and evaluate the impact of water resource management. This article presents a comprehensive comparative analysis of various water sustainability indices, emphasizing their underlying principles, methodologies, and potential applications. Our study reveals the diverse landscape of existing indices, illustrating that even indices with similar names can vary significantly in scope and methodology. Via a systematic review of 124 publications, this study provides insights into existing composite indices related to water sustainability, highlighting their specific applications and potential contributions to water resource management and sustainability. The information gathered from the selected papers was synthesized and analyzed thematically to identify common patterns through keyword co-occurrence mapping, SDG mapping, standard review protocols, and cluster analyses. Through a cluster analysis, we identified six distinct clusters of indices, highlighting the need for careful consideration in selecting appropriate ones. Moreover, our analysis of co-occurring keywords underscores the close relationship between sustainable development, water resources, water supply, and water conservation within the context of water-related indices. Notably, these indices address not only sustainable development goal six but also a number of other interconnected goals. It was also found that “sustainability index” is a common name for different nature water indices. This review also identifies research gaps in the existing literature. However, significant limitations exist, including a lack of historical application and future projections for many current water sustainability indicators. Without the ability to track changes over time and project the future, identifying areas of improvement and measuring progress toward long-term water sustainability goals becomes challenging. Furthermore, many indices are complex and designed for watershed or regional levels, limiting their adaptability to different contexts. Despite these challenges, indices remain valuable tools for assessing and managing water resources sustainably, addressing various dimensions of sustainability, and supporting decision-making processes across different sectors and contexts.

Optimizing nitrogen use efficiency of six forage grasses to reduce nitrogen loss from intensification of tropical pastures

We aimed to evaluate the effect of different types and rates of nitrogen (N) fertilizers on plant biomass production, nitrogen use efficiency (NUE), and nitrous oxide (N2O) emissions of six tropical forage grass cultivars. This field study was conducted in Colombia under tropical conditions in two phases. Phase 1: we evaluated the effect of different types of N fertilizers (urea; calcium ammonium nitrate (CAN); and urea-ammonium sulfate (U-AS) using a single dose of application of 25 kg N ha−1 cut−1, along with a control treatment for each grass without application of fertilizer) on forage dry matter, crude protein, N uptake, N surplus, and NUE. The study focused on six tropical forage grass cultivars: Urochloa humidicola cv. Tully, U. hybrid cv. Cobra, U. hybrid cv. Cayman, Megathyrsus maximus cv. Mombasa, Cynodon nlemfuensis cv. Stargrass and U. decumbens cv. Basilisk. We found that the biomass production and protein content of each forage grass cultivar responded differently to different N fertilizer types. In consequence, the NUE of each forage grass cultivar was strongly affected by the type of N fertilizer applied. For example, Cayman showed a NUE of 87.8% with CAN and 40.4% with urea, while the NUE of Basilisk with CAN was 8.0% and 76.4% with urea. Maximum NUE values were obtained for Stargrass and Cayman with CAN (91.7 and 87.8%, respectively) and for Mombasa with urea (89.9%). Phase 2: we selected three combinations of forage grass cultivars and type of N fertilizer, and we evaluated the impact of four rates of N application (0, 10, 20, and 30 kg N ha−1 cut−1) on forage production and N2O emissions upon fertilization. In general, higher N fertilization rates increased the accumulated N2O emissions. However, we observed that the fertilization of Stargrass and Cayman grass with a rate of 20 kg N−1 cut−1 and Mombasa grass with a rate of 30 kg N−1 cut−1 were more beneficial than the other rates of N fertilization based on the biomass production and amount of N2O emitted are considered. This study highlights the importance of optimizing NUE in tropical pasture systems using an appropriate design of N fertilization strategy. Inappropriate N fertilizer use can significantly increase the N losses (e.g., through N2O emissions, with a potential contribution from N leaching). These findings provide valuable information for sustainable intensification of productive tropical livestock systems to spare land for other uses.

Up-gradation of the dielectric, physical & chemical properties of cottonseed-based, non-edible green nanofluids as sustainable alternatives for high-voltage equipment's insulation fluids

The use of natural ester oils as electrically insulating fluids has gained significant attention from industries and electrical utilities as they aim to replace traditional mineral oils. However, most natural ester oils are derived from edible products, which has the potential to contribute to the food crisis. Therefore, nonedible green nanofluids made from cottonseed oil (CSO) have been targeted as a keen solution to this issue. However, Al2O3, TiO2, Fe2O3, SiO2, and graphene nanoparticles at (0.025, 0.05, and 0.075 wt/vol%) were used as additives, along with surfactant Olic Ac-id and Ethanol (1:5) due to their promising impact on the dielectric and thermal properties of the nanofluid. The nanofluid synthesis process was practically conducted in HV & Chemical Laboratories using one-step and two-step methods, and their breakdown voltage results and chemical properties (e.g., fire point, flash point, cloud point, pour point, viscosity, acidity, moisture content, resistivity, and dissipation factor) were compared. The physical mechanisms underlying these properties were also analyzed and tested. For the validation of the proposed vegetable oil the results have been compared with traditional mineral oil for high-voltage equipment's. The findings suggest that the proposed nonedible green nanofluids-based cottonseed oil (CSO) has a high potential to be used as electrically insulating fluids, providing a sustainable alternative to conventional mineral oils. Overall, this study provides insights into the use of non-edible green nanofluids as a solution to the potential contribution of natural ester oils to the food crisis. The findings highlight the importance of sustainable solutions in the energy industry and the need for further research in this area.

Effect of microplastics used in agronomic practices on agricultural soil properties and plant functions: Potential contribution to the circular economy of rural areas.

The extensive use of plastic materials and their improper disposal results in high amounts of plastic waste in the environment. Aging of plastics leads to their breakdown into smaller particles, such as microplastics (MPs) and nanoplastics. This research investigates plastics used in agricultural practices as they contribute to MP pollution in agricultural soils. The distribution and characteristics of MPs in agricultural soils were evaluated. In addition, the effect of MPs on soil properties, the relationship between MPs and metals in soil, the effect of MPs on the fate of pesticides in agricultural soils and the influence of MPs on plant growth were analysed, discussing legume, cereal and vegetable crops. Finally, a brief description of the main methods of chemical analysis and identification of MPs is presented. This study will contribute to a better understanding of MPs in agricultural soils and their effect on the soil-plant system. The changes induced by MPs in soil parameters can lead to potential benefits as it is possible to increase the availability of micronutrients and reduce plant uptake of toxic elements. Furthermore, although plastic pollution remains an emerging threat to soil ecosystems, their presence may result in benefits to agricultural soils, highlighting the principles of the circular economy.

Virus-Associated CD8+ T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions.

Viral infections have been associated with the progression of atherosclerosis and CD8+ T-cells directed against common viruses, such as influenza, Epstein-Barr virus, and cytomegalovirus, have been detected inside human atherosclerotic lesions. These virus-specific CD8+ T-cells have been hypothesized to contribute to the development of atherosclerosis; however, whether they affect disease progression directly remains unclear. In this study, we aimed to characterize the activation status of virus-specific CD8+ T-cells in the atherosclerotic lesion. The presence, clonality, tissue enrichment, and phenotype of virus-associated CD8+ T-cells in atherosclerotic lesions were assessed by exploiting bulk T-cell receptor-β sequencing and single-cell T-cell receptor (α and β) sequencing datasets on human endarterectomy samples and patient-matched blood samples. To investigate if virus-specific CD8+ T-cells can be activated through T-cell receptor stimulation in the atherosclerotic lesion, the immunopeptidome of human plaques was determined. Virus-associated CD8+ T-cells accumulated more in the atherosclerotic lesion (mean=2.0%), compared with patient-matched blood samples (mean=1.4%; P=0.05), and were more clonally expanded and tissue enriched in the atherosclerotic lesion in comparison with nonassociated CD8+ T-cells from the lesion. Single-cell T-cell receptor sequencing and flow cytometry revealed that these virus-associated CD8+ T-cells were phenotypically highly similar to other CD8+ T-cells in the lesion and that both exhibited a more activated phenotype compared with circulating T-cells. Interestingly, virus-associated CD8+ T-cells are unlikely to be activated through antigen-specific interactions in the atherosclerotic lesion, as no virus-derived peptides were detected on HLA-I in the lesion. This study suggests that virus-specific CD8+ T-cells are tissue enriched in atherosclerotic lesions; however, their potential contribution to inflammation may involve antigen-independent mechanisms.

Plethysmography: A game changer for chronic venous insufficiency diagnosis, treatment, and follow-up.

Chronic Venous Insufficiency (CVI) presents a various clinical symptoms and treatment options. Although it is generally known which treatment option is more appropriate in which situations in CVI, it is even more difficult to find the right option in some uncertain situations. In this study, we aimed to evaluate the potential contribution of Digital Photoplethysmography (D-PPG) in the diagnosis of CVI and especially in the selection of treatment options. This retrospective study was conducted at Bursa Heart and Arrhythmia Hospital, involving 721 consecutive patients diagnosed with CVI and with Endovenous Laser Ablation (EVLA) indication. The patients were divided into 2 groups according to the extent of the failure in Doppler USG. In Group 1, the insufficiency ended above the knee, and in Group 2, the insufficiency progressed to below the knee. Patients were evaluated based on anamnesis, physical examination, Doppler USG, and D-PPG. Clinical classification, Venous Clinic Severity Score (VCSS), Quality of Life (QoL) assessment, venous pump capacity (VPC), and venous refill time (VRT) were measured. The study included 263 male and 458 female patients with a mean age of 52.37 ± 12.26years. Significant differences were observed between Group 1 (above knee reflux) and Group 2 (below knee reflux) patients in terms of VCSS, QoL, VPC, and VRT values. The mean values of VCSS, patient complaints, VPC, and VRT were higher in Group 2 patients. Similar findings were observed within the CEAP 2 subgroup. D-PPG shows potential as a valuable tool in the diagnosis and treatment of CVI. By providing information about venous hemodynamics and volume changes, it can assist in optimizing treatment decisions, including saphenous vein preservation. Combining D-PPG with Doppler USG may improve the comprehensive assessment of CVI and change the treatment option, especially for CEAP 2 patients. More research is needed to confirm these findings and explore wider applications of plethysmographic methods in the management of CVI.

Russian women, Ukraine war, and (Neglected) writing on the wall: From the (Im)possibility of world traveling to failing feminist alliances

ABSTRACT We argue that the Russian feminist and resistance groups, Pussy Riot, Feminist Antiwar Resistance, and Les Pleureuses, operate and should be acknowledged as agents of social change, and leaders of cultural opposition during the current Russia-Ukraine war. We establish Second World Feminism and Russian feminism as its cultural product in this essay. We argue how, in the years preceding the war, Pussy Riot repeatedly protested the totalitarian grip of the Russian state, its corruption, and the concretion of the Russian Orthodox Church and the state in creating conditions of female obedience and oppression. Further, we analyze the emergence and the ongoing activism of the anti-war resistance movement, FAR and its branch Les Pleureuses, in their fight against war, patriarchy, authoritarianism, and militarism. We illustrate how and why Russian feminists/resistance groups became agents of dissent, and can become torchbearers of peace. We examine the collectives’ potential contribution to and compatibility with transnational feminist alliances and make a case for including both Russian and Second World Feminisms as meaningful and impactful perspectives within the framework of transnational feminism.

Creativity and digital strategies to support food cultural heritage in Mediterranean rural areas

PurposeThe purpose of this study is to address the challenges faced by rural areas and promote their sustainable development. It emphasizes the importance of re-establishing connections and cultivating a sense of belonging within rural communities, while safeguarding their cultural heritage. The study explores the potential of digital and creative tools in enhancing learning, supporting food production and tourism, facilitating research and providing engaging experiences. It also examines the economic condition of rural areas and the potential for their contribution to the national economy. Additionally, the study highlights the significance of sustainable community development, the role of rural areas in resilience and climate change adaptation and the complexities surrounding rural migration. The aim is to provide insights and recommendations for policymakers and stakeholders involved in rural development initiatives, focusing on the Mediterranean region.Design/methodology/approachThis study develops an understanding of the role of digital and creative strategies in rural communities, highlighting their significance in preserving food heritage, culture and community capital while driving economic development. It specifically focuses on the Unesco Intangible Mediterranean Diet (UIMD) as a potential catalyst for regeneration through the integration of creative and digital tools and three cases are presented. The first is the impact of the Future Food Institute (FFI) ecosystem in the Living Lab in Pollica (Salerno, Italy); the second focuses on the digital tools provided by the CKF to support rural areas; and the third is a new identity and promotion of territorial development, co-designed in the Val di Vara (VdV) a rural region of the Ligurian inland in Italy, through digital strategies, heritage preservation and slow tourism development. The three cases highlight different ways of enhancing environmental and cultural heritage and demonstrate how collaborative creativity and digital tools contribute to the co-construction of knowledge and addressing critical issues to promote sustainable growth in rural areas.FindingsThe findings of this study indicate that re-establishing connections and fostering a sense of belonging within rural communities is crucial for their sustainable development. The use of digital and creative tools presents significant opportunities in enhancing various aspects such as learning, food production, tourism and research in rural areas. The study also reveals the potential economic contributions of rural areas to the national economy. It emphasizes the importance of sustainable community development and highlights the role of rural areas in resilience and climate change adaptation. Additionally, the study addresses the complexities surrounding rural migration and emphasizes the need for comprehensive policies to ensure the well-being and rights of migrant workers. The insights and recommendations provided in this study aim to guide policymakers and stakeholders involved in rural development initiatives, particularly in the Mediterranean region.Research limitations/implicationsNonetheless, it is imperative to acknowledge certain limitations within the scope of this study, primarily associated with the specific sample selection, potentially influencing the broader applicability of the findings. There is potential to explore a wider geographic area in future research. Additionally, the research underscores the importance of conducting further inquiries into certain aspects that have received limited attention. Living labs are a relatively recent phenomenon, warranting further in-depth scientific research. Additionally, the existing literature on this subject is often limited in scope.Practical implicationsThe study and project aim to illustrate the feasibility of initiating a transformative process, centered on a visionary approach with a core focus on creative knowledge and the Mediterranean diet as a way of life, to revitalize marginalized communities. Furthermore, it seeks to emphasize that these neglected regions possess untapped potential for innovative ideas and opportunities. Rural communities, in their role as farmers of primary goods, are the ones who nurture the environment, and the landscape, and are the true protagonists of every era. Rurality is the place that preserves the most resources and potential in terms of biodiversity and rural knowledge. Every territory, like every human being, has its own characteristics and vocations to pursue. The existing Genius Loci is already an existing value that requires policies and governance to rediscover roots, identity and worth. The stratification of existing collective intelligence must become central and must be individually assessed and enhanced, also taking advantage of new digital technologies.Social implicationsThe social implications of this study are significant. By emphasizing the importance of re-establishing connections and cultivating a sense of belonging within rural communities, the study recognizes the social value of strong community ties. This can lead to increased social cohesion, a sense of identity and improved overall well-being within rural areas. The study also highlights the potential of digital and creative tools in enhancing learning, which can contribute to the empowerment and educational opportunities of individuals in rural communities. Furthermore, by promoting sustainable community development and addressing the complexities surrounding rural migration, the study acknowledges the social impact of inclusive policies that protect the rights and well-being of both local populations and migrant workers. Overall, the study's recommendations have the potential to foster social resilience, equity and a more vibrant social fabric within rural areas.Originality/valueThis study can offer valuable insights and recommendations for policymakers and stakeholders involved in rural development initiatives, particularly those focused on preserving food and cultural heritage in rural areas. By analyzing real-life examples, it bridges the gap between theory and practice, illustrating how these ideas have been effectively applied in specific contexts. This paper emphasizes the potential of the Mediterranean Diet as a sustainable and nutritious model with sociocultural, health, economic and environmental benefits, highlighting the importance of bottom-up approaches that empower local communities as custodians of knowledge and culture. It also provides practical strategies, such as investments in educational programs, the establishment of international campuses and the use of multichannel platforms for immersive experiences, which can be adapted for broader rural development initiatives, promoting sustainability and community engagement.

Opinions and Beliefs of Adults with Intellectual Disabilities or Visual Impairment about Research with Routine Care Data

Research with routine care data (RCD) is not always a transparent process to the people receiving care for disabilities or impairment. This study aimed to understand the point of view on secondary use of care data for research from the people with visual or intellectual disabilities themselves. In total 36 participants from the UK and the Netherlands were interviewed (20 with intellectual disabilities, 16 with visual impairment). Transcripts were analysed inductively using the Framework Approach. Interview results showed that people from both countries and disability groups assumed that RCD research took place and saw potential contributions to care quality as grounds for legitimacy. Their themes of concern were about inaccuracy and threats to anonymity of data. Interviewees made suggestions for improving conditions under which RCD research can happen with informed consent. In addition to informing data governance policies of organisations serving people with disabilities, findings underscore the contribution that people with disabilities can make to data governance.

Multifunctional MXene-Based Platforms for Soft and Bone Tissue Regeneration and Engineering.

MXenes and their composites hold great promise in the field of soft and bone tissue regeneration and engineering (TRE). However, there are challenges that need to be overcome, such as ensuring biocompatibility and controlling the morphologies of MXene-based scaffolds. The future prospects of MXenes in TRE include enhancing biocompatibility through surface modifications, developing multifunctional constructs, and conducting in vivo studies for clinical translation. The purpose of this perspective about MXenes and their composites in soft and bone TRE is to critically evaluate their potential applications and contributions in this field. This perspective aims to provide a comprehensive analysis of the challenges, advantages, limitations, and future prospects associated with the use of MXenes and their composites for soft and bone TRE. By examining the existing literature and research, the review seeks to consolidate the current knowledge and highlight the key findings and advancements in MXene-based TRE. It aims to contribute to the understanding of MXenes' role in promoting soft and bone TRE, addressing the challenges faced in terms of biocompatibility, morphology control, and tissue interactions.

Pediatric Hearing Aid Daily Wear Time Is Significantly Impacted by Clinician-Family Language Discordance.

The purpose of this study was to evaluate the potential contribution of limited English proficiency on daily hearing aid wear time for children with hearing loss. A retrospective chart review was completed to evaluate hearing aid wear time based on data logging information available at the time of a follow-up visit following an initial hearing aid fitting. Children were included in the study if they had permanent bilateral hearing loss and were less than 60 months of age at the time of their first follow-up visit. Wear time was compared between children who attended an interpreter-mediated appointment and those who did not have an interpreter present. The presence of an interpreter at the appointment was the study indicator that the family had limited English proficiency. Children from families with limited English proficiency exhibited significantly shorter daily wear time (M = 1.3 hr) than their peers whose families were English-proficient speakers, thus, having a shared language with their audiologists (M = 5.2 hr). Results of this study suggest that family-clinician language discordance might put children at greater risk of shorter hearing aid wear time than children whose caregivers share a common language with their child's audiologist. There can be many linguistic, cultural, and educational factors that contribute to hearing aid wear time in children whose families have limited English proficiency as well as different approaches to improving that wear time. Efforts should ensure that hearing and hearing aid-related information is accessible to all families, especially those with clinician-family language discordance. Such efforts can include, among others, training that improves clinicians' cultural and linguistic responsiveness to the diverse families they serve.

A Comprehensive Review on Peptic Ulcer

Abstract: Up to 10% people in the world are affected by a chronic condition known as peptic ulcer. Peptic ulcer development is influenced by the pH of gastric juice and a decline in mucosal defenses. Protonpump inhibitors, histamine (H2) receptor antagonists, prostaglandin analogues and sucralfate have all been used to treat peptic ulcer disease. There has been a continuing search for an appropriate, palliative, and curative agent for the treatment of peptic ulcer disease using natural materials of plant and animal origin due to the complexity, cost, and toxicity of these medications. The goal of this review was to examine medicinal plants, phytochemicals, pathways, and research models that have been applied to the treatment of PUD in order to assess the potential contribution of natural substances to the development of herbal treatments for PUD. A literature search was used to find information utilising electronic databases such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane.

Impact of talker variability on language development in two-year-olds.

This research investigated the impact of the number of talkers with whom children engage in daily conversation on their language development. Two surveys were conducted in 2020, targeting two-year-olds growing up in Japanese monolingual families. Caregivers reported the number of talkers in three age groups and children's productive vocabulary via questionnaires. The results demonstrated significant effects of variability in talkers in fifth grade or above in Study 1 (N = 50; male = 23; r = .372) and in adult talkers in Study 2 (N = 175; non-nursery going; male = 76; r = .184) on children's vocabulary development, after controlling for language exposure time and demographic variables. Possible mediating factors are discussed. This research extends previous findings from immigrant bilingual children to monolingual speakers in Japan, suggesting the potential contribution of available talkers other than caregivers in conversational environments.

Do Individual Differences in Perception Affect Awareness of Climate Change?

One significant obstacle to gaining a widespread awareness of the ongoing climate change is the nature of its manifestations in relation to our perception: climate change effects are gradual, distributed, and sometimes seemingly contradictory. These features result in a lag in collective climate action and sometimes foster climate skepticism and climate denial. While the literature on climate change perception and belief has thoroughly explored its sociocultural and sociopolitical aspects, research on the potential contribution of psychophysiological factors remains scarce. In this perspective paper, we outline evidence and arguments for the involvement of psychophysiological systems such as thermoception, hygroreception, and interoception in modulating climate change awareness. We discuss psychophysiological mechanisms of climate change awareness in animals and humans, as well as possible sources of individual variance in climate change perception. We conclude by suggesting novel research questions which would be worthwhile to pursue in future studies.

[Analysis of the Jumping Characteristics and Influencing Factors of Ozone Pollution in Beijing].

Based on environmental monitoring data and meteorological observation data from 2016 to 2022 in Beijing, combined with backward trajectory clustering and potential source area contribution analysis, the characteristics, meteorological impacts, and potential source areas of ozone (O3) pollution were analyzed. The results showed that there was a total of 41 O3 pollution processes with jumping characteristics in Beijing from 2016 to 2022, with an average of 5.9 times a year. The occurrence time was concentrated in May to July, and the day of the jump (OJD2) was higher than the day before the jump (OJD1). The average value of ρ(O3-8h) was 78.3% higher, and the peak concentration was 78.9% higher. The high O3 concentration zone in the OJD2 region exhibited a characteristic of advancing from south to north. The main reasons for the occurrence of jumped O3 pollution in Beijing could be summarized as local accumulation caused by unfavorable meteorological conditions and regional transmission impact. The occurrence of jump-type ozone pollution was characterized by an increase in southerly wind frequency, temperature rise, pressure decrease, and precipitation decrease. The increase in southerly wind frequency provided conditions for the transport of O3 and its precursors, and rapid photochemical reactions occurred under local high temperatures, with less superimposed precipitation, comprehensively pushing up the ozone concentration level of OJD2. Six air mass transporting pathways were identified through clustering analysis; the air mass from the direction north of OJD2 decreased by 11.2%, whereas the air mass from the south and east directions increased by 6.7% and 4.4%, respectively, with the air masses mainly transmitting over short distances. The ozone concentration corresponding to the south and east directions was relatively high, making a significant contribution to Beijing's pollution. The analysis of potential source areas revealed that the main potential source areas of OJD2 ozone pollution were the central, southern, and eastern parts of Beijing-Tianjin-Hebei, which contributed 82.6% to the pollution trajectory. There was a significant contribution of regional transport during jump-type ozone pollution, and it is necessary to strengthen joint prevention and control in the Beijing-Tianjin-Hebei Region.

The effect of carbohydrate intake on sleep quality and exercise performance

Carbohydrates are essential nutrients within the context of our daily dietary intake, serving a crucial function in the provision of energy for human metabolism, as well as exerting a significant influence on athletic performance and the subsequent process of recuperation. Carbohydrates, being a primary source of energy for the human body, hold significant significance in our daily existence. Carbohydrates serve multiple functions, including the reduction of body protein consumption, possession of detoxifying qualities, and potential contribution to an extended lifespan through acceptable ingestion. The appropriate consumption of carbohydrates significantly influences the overall health and quality of life of those without any specific health conditions. The dietary intake of an athlete plays a pivotal role in determining their performance on the field. Carbohydrates provide a primary energy source within the dietary regimen of athletes, playing a pivotal role in fueling explosive power, endurance, and other critical determinants of athletic success. The significance of carbs in relation to sleep should not be overlooked. The objective of this paper is to investigate the influence of carbohydrate consumption on both exercise performance and sleep quality. Additionally, this study will undertake a more extensive examination and analysis by include both athletes and individuals from the general population.

Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick: An Expert Consensus Paper.

With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (1) determine the potential contribution of the DOAC to spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates for reversal, or (3) optimize the timing of urgent surgery or intervention. The DOAC Dipstick test uses a disposable strip to identify factor Xa- or thrombin inhibitors in a urine sample. Based on the results of a systematic literature search followed by an analysis of a simple pooling of five retrieved clinical studies, the test strip has a high sensitivity and an acceptably high negative predictive value when compared with levels measured with liquid chromatography tandem mass spectrometry or calibrated chromogenic assays to reliably exclude plasma DOAC concentrations ≥30 ng/mL. Based on these data, a simple algorithm is proposed to enhance medical decision-making in acute care indications useful primarily in hospitals not having readily available quantitative tests and 24/7. This algorithm not only determines DOAC exposure but also differentiates between factor Xa and thrombin inhibitors to better guide clinical management.

A differential impact of action-effect temporal contiguity on different measures of response inhibition in the Go\No-Go and Stop-signal paradigms.

Response inhibition refers to suppressing a prepotent motor response and is often studied and discussed as an act of cognitive control. Much less attention was given to the potential contribution of motor control processes to response inhibition. Accumulated empirical findings show that a perceptual effect temporally contiguous with a response improves motor control performance. In the current study, we followed this work by manipulating action-effect temporal contiguity to enhance motor performance and investigated its impact on response selection and inhibition. In two experiments, we integrated a Go/No-Go (GNGT; Experiment 1) and a Stop-signal (SST; Experiment 2) task with the Effect-Motivation task, previously used to capture the facilitating impact of action-effect temporal contiguity on response times (RTs). Replicating previous findings, RTs were shorter following temporally contiguous compared to Lagged action-effect in Go trials in both the GNGT (Experiment 1) and SST (Experiment 2). Notably, an Immediate action-effect improved response inhibition in the GNGT (Experiment 1) but did not modulate Stop-signal reaction time (SSRT) in the SST (Experiment 2). Unexpectedly, the error rate on Go trials was higher in the Immediate effect condition in Experiment 2. We interpret the findings to suggest that an action's (Immediate) perceptual effect may promote response inhibition performance by enhancing selective association between the Go stimuli and the Go response and not by improving cognitive control ability. The findings also imply that an Immediate action-effect may hamper action control (e.g., by increasing general readiness to respond), at least when action control does not benefit from automatic stimulus-response association.

Can mental health practice benefit from procedural justice theory? A critical analysis on the opportunities and pitfalls of procedural justice to address coercion and human rights issues in psychiatry

The theory of procedural justice, derived from social psychology, is employed in numerous fields of study concerned with the quality of interactions involving individuals in positions of authority. Although this theory is increasingly cited for its potential to promote approaches aimed at mitigating the effects of psychiatric coercion and better respecting individuals' rights, empirical literature provides limited insights into how procedural justice could be translated into practice. It is important, therefore, to examine the theoretical and practical implications of such an orientation. Based on a critical analysis of existing literature, this article will discuss the potential contributions and limitations of procedural justice applied in the field of mental health and psychiatric nursing. Procedural justice has limitations regarding solutions for human rights violations in psychiatry. It nonetheless allows a focus on the quality of interactions with individuals in coercive contexts, in addition to considering the social and identity-related implications of psychiatric coercion.